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|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EML4 - ALK ALK G1202R||Advanced Solid Tumor||sensitive||TPX-0131||Preclinical - Cell culture||Actionable||In a preclinical study, TPX-0131 treatment inhibited Alk phosphorylation and viability of transformed cells expressing EML4-ALK with ALK G1202R in culture (PMID: 36201110).||36201110|
|EML4 - ALK ALK G1202R||Advanced Solid Tumor||sensitive||TPX-0131||Preclinical - Cell line xenograft||Actionable||In a preclinical study, TPX-0131 inhibited Alk autophosphorylation and proliferation of transformed cells expressing ALK G1202R in the context of EML4-ALK in culture and resulted in complete tumor growth inhibition in a mouse cell line xenograft model (PMID: 34158340).||34158340|