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Molecular Profile PTEN dec exp
Therapy Fluorouracil + Ipatasertib + Leucovorin + Oxaliplatin
Indication/Tumor Type gastroesophageal cancer
Response Type no benefit


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN dec exp gastroesophageal cancer no benefit Fluorouracil + Ipatasertib + Leucovorin + Oxaliplatin Phase II Actionable In a Phase II trial, the combination of Ipatasertib (GDC-0068) and mFOLFOX6 did not improve median progression-free survival (7.1 vs 7.4 months; HR=1.07, p=0.86) compared to placebo plus mFOLFOX6 in patients with advanced gastroesophageal junction or gastric cancer harboring decreased PTEN expression (IHC=0 in >10% of tumor cells) (PMID: 30592991; NCT01896531). 30592991
PubMed Id Reference Title Details
(30592991) A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer. Full reference...