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Molecular Profile | HRAS Q61K |
Therapy | Rigosertib |
Indication/Tumor Type | rhabdomyosarcoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
HRAS Q61K | rhabdomyosarcoma | sensitive | Rigosertib | Preclinical - Cell culture | Actionable | In a preclinical study, Rigosertib (ON01910) inhibited cell viability and induced apoptosis and cell cycle arrest in rhabdomyosarcoma cells harboring HRAS Q61K in culture (PMID: 33158997). | 33158997 |
PubMed Id | Reference Title | Details |
---|---|---|
(33158997) | Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma. | Full reference... |