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|Molecular Profile||BRAF V600E|
|Therapy||Dabrafenib + SCH772984|
|Indication/Tumor Type||thyroid gland cancer|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E||thyroid gland cancer||sensitive||Dabrafenib + SCH772984||Preclinical - Cell line xenograft||Actionable||In a preclinical study, combination treatment with Tafinlar (dabrafenib) and SCH772984 synergistically inhibited cell growth of thyroid cancer cell lines harboring BRAF V600E in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 33595872).||33595872|
|PubMed Id||Reference Title||Details|
|(33595872)||Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.||Full reference...|