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Molecular Profile BRAF V600E
Therapy Ruxolitinib + Vemurafenib
Indication/Tumor Type hairy cell leukemia
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E hairy cell leukemia predicted - sensitive Ruxolitinib + Vemurafenib Phase II Actionable In a Phase II trial (HCL-PG03), combined Zelboraf (vemurafenib) and Jakafi (ruxolitinib) therapy in relapsed or refractory hairy cell leukemia patients with BRAF V600E demonstrated safety, and led to complete response (CR) in 87% (26/30) of patients, including 17 (65%) with negative minimal residual disease, a progression-free survival rate of 78% at a median follow-up of 37 months, and a relapse-free survival rate of 85% in the 26 patients with a CR at a median follow-up of 34 months (PMID: 33979489). 33979489
PubMed Id Reference Title Details
(33979489) Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia. Full reference...