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Molecular Profile BRAF V600E
Therapy Dabrafenib + Rabeprazole + Rifampin
Indication/Tumor Type endometrial adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E endometrial adenocarcinoma predicted - sensitive Dabrafenib + Rabeprazole + Rifampin Case Reports/Case Series Actionable In a Phase I trial, combination treatment with Tafinlar (dabrafenib), Rabeprazole, and Rifampin in a patient with metastatic endometrial adenocarcinoma harboring BRAF V600E, that recurred 11 years after original diagnosis and was refractory to treatment with chemotherapy, led to reduction of lung metastases and pelvic tissue mass at three months, but a slight increase in pelvic mass was observed at six months (PMID: 33537843; NCT01954043). 33537843
PubMed Id Reference Title Details
(33537843) BRAF/MEK inhibitors for BRAF V600E-mutant cancers in non-approved setting: a case series. Full reference...