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Molecular Profile EML4 - ALK ALK G1202R
Therapy Ceritinib
Indication/Tumor Type lung non-small cell carcinoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK G1202R lung non-small cell carcinoma resistant Ceritinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing EML4-ALK with ALK G1202R were insensitive to Zykadia (ceritinib) in culture (PMID: 24675041). 24675041
EML4 - ALK ALK G1202R lung non-small cell carcinoma resistant Ceritinib Case Reports/Case Series Actionable In a clinical case study, a non-small cell lung carcinoma patient harboring EML4-ALK who acquired the secondary drug resistance mutation, ALK S1206Y, when treated with Xalkori (crizotinib) was subsequently treated with Zykadia (ceritinib), developed drug resistance, and was then found to have lost the ALK S1206Y mutation, but gained ALK G1202R (PMID: 24675041). 24675041
PubMed Id Reference Title Details
(24675041) The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Full reference...
(24675041) The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Full reference...