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Molecular Profile | BTK T474M BTK C481T |
Therapy | CGI1746 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BTK T474M BTK C481T | Advanced Solid Tumor | predicted - resistant | CGI1746 | Preclinical - Biochemical | Actionable | In a preclinical study, treatment with CGI1746 failed to inhibit Btk activity in a cell line expressing BTK variants T474M and C481T in culture (PMID: 33526860). | 33526860 |
PubMed Id | Reference Title | Details |
---|---|---|
(33526860) | BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib. | Full reference... |