Profile Response Detail


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Molecular Profile FGFR1 V592M FGFR1 K687E
Therapy Debio 1347
Indication/Tumor Type glioblastoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 V592M FGFR1 K687E glioblastoma predicted - sensitive Debio 1347 Case Reports/Case Series Actionable In a clinical case study, Debio 1347 treatment resulted in a near complete response with a 96.3% maximal tumor reduction after 2 months of therapy in a pediatric patient with spinal cord glioblastoma harboring FGFR1 V592M and FGFR1 K687E, and the response was maintained for 11 months (PMID: 34250399). 34250399
PubMed Id Reference Title Details
(34250399) Debio1347, an Oral FGFR Inhibitor: Results From a Single-Center Study in Pediatric Patients With Recurrent or Refractory FGFR-Altered Gliomas. Full reference...