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|Profile Name||FGFR1 V592M FGFR1 K687E|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR1 V592M FGFR1 K687E||pilomyxoid astrocytoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a clinical case study, Debio 1347 treatment resulted in a significant clinical improvement and sustained stable disease at 14 months with a 12.2% maximal tumor reduction in a pediatric patient with optic pathway pilomyxoid astrocytoma harboring FGFR1 V592M and FGFR1 K687E (PMID: 34250399).||34250399|
|FGFR1 V592M FGFR1 K687E||glioblastoma||predicted - sensitive||Debio 1347||Case Reports/Case Series||Actionable||In a clinical case study, Debio 1347 treatment resulted in a near complete response with a 96.3% maximal tumor reduction after 2 months of therapy in a pediatric patient with spinal cord glioblastoma harboring FGFR1 V592M and FGFR1 K687E, and the response was maintained for 11 months (PMID: 34250399).||34250399|