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Molecular Profile | FGFR1 V561M |
Therapy | Ponatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 V561M | Advanced Solid Tumor | predicted - resistant | Ponatinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing FGFR1 V561M demonstrated insensitivity to Iclusig (ponatinib) in culture (PMID: 34114373). | 34114373 |
PubMed Id | Reference Title | Details |
---|---|---|
(34114373) | GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. | Full reference... |