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Molecular Profile | FGFR1 V561M |
Therapy | HQP1351 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR1 V561M | Advanced Solid Tumor | sensitive | HQP1351 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GZD824 (HQP1351) treatment inhibited cell growth and Fgfr1 phosphorylation and downstream pathway activation in cells expressing FGFR1 V561M in culture and inhibited tumor growth in cell line xenograft models, with a tumor growth inhibition of 49.8% (PMID: 34114373). | 34114373 |
PubMed Id | Reference Title | Details |
---|---|---|
(34114373) | GZD824 overcomes FGFR1-V561F/M mutant resistance in vitro and in vivo. | Full reference... |