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Molecular Profile | IDH1 R132H |
Therapy | Ceralasertib + Olaparib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 R132H | Advanced Solid Tumor | sensitive | Ceralasertib + Olaparib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Lynparza (olaparib) and Ceralasertib (AZD6738) resulted in a greater decrease in cell survival compared to Ceralasterib (AZD6738) alone in cells expressing IDH1 R132H in culture, and a longer delay in tumor growth in cell line xenograft models (PMID: 34027408). | 34027408 |
PubMed Id | Reference Title | Details |
---|---|---|
(34027408) | Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. | Full reference... |