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Molecular Profile | BARD1 D135N |
Therapy | Fluzoparib |
Indication/Tumor Type | breast cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BARD1 D135N | breast cancer | predicted - sensitive | Fluzoparib | Preclinical - Cell culture | Actionable | In a preclinical study, Fluzoparib (SHR3162) treatment inhibited proliferation of a BARD1-deficient breast cancer cell line expressing BARD1 D135N in culture (PMID: 33933153). | 33933153 |
PubMed Id | Reference Title | Details |
---|---|---|
(33933153) | Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patient. | Full reference... |