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Molecular Profile | RET G810R |
Therapy | APS03118 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET G810R | Advanced Solid Tumor | predicted - sensitive | APS03118 | Preclinical - Cell culture | Actionable | In a preclinical study, APS03118 inhibited the enzymatic activity of RET G810R in an in vitro assay and inhibited Ret phosphorylation and proliferation of cells expressing RET G810R in culture (J Clin Oncol 40, no. 16_suppl (June 1, 2022)). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
The development of APS03118, a potent next-generation RET inhibitor for treating RET-inhibitor-resistant patients. | Full reference... |