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Molecular Profile | KIT D419del |
Therapy | Imatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D419del | Advanced Solid Tumor | predicted - sensitive | Imatinib | Preclinical - Biochemical | Actionable | In a preclinical study, Gleevec (imatinib) treatment inhibited Kit autophosphorylation in transformed cells expressing KIT D419del in culture (PMID: 16143141). | 16143141 |
PubMed Id | Reference Title | Details |
---|---|---|
(16143141) | Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. | Full reference... |