Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Molecular Profile | KIT V560D |
Therapy | Sorafenib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560D | Advanced Solid Tumor | sensitive | Sorafenib | Preclinical | Actionable | In a preclinical study, transformed cells expressing KIT V560D were sensitive to Nexavar (sorafenib) in culture (PMID: 22665524). | 22665524 |
PubMed Id | Reference Title | Details |
---|---|---|
(22665524) | Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors. | Full reference... |