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Molecular Profile | FLT3 exon 14 ins FLT3 R845G |
Therapy | Gilteritinib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 R845G | hematologic cancer | sensitive | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Xospata (gilteritinib) resulted in reduced cell viability in transformed cells expressing FLT3 ITD with FLT3 R845G in culture (PMID: 32040554). | 32040554 |
PubMed Id | Reference Title | Details |
---|---|---|
(32040554) | Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations. | Full reference... |