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Molecular Profile | PALB2 L24F PALB2 Y551* |
Therapy | Olaparib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PALB2 L24F PALB2 Y551* | Advanced Solid Tumor | sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, expressing PALB2 L24F sensitized transformed human cells harboring PALB2 Y551* to Lynparza (olaparib) treatment in culture (PMID: 35853885). | 35853885 |
PubMed Id | Reference Title | Details |
---|---|---|
(35853885) | Functional assessment of missense variants of uncertain significance in the cancer susceptibility gene PALB2. | Full reference... |