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Molecular Profile | NRAS mutant |
Therapy | FCN-159 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS mutant | Advanced Solid Tumor | predicted - sensitive | FCN-159 | Preclinical - Pdx | Actionable | In a preclinical study, FCN-159 inhibited tumor growth in patient-derived xenograft (PDX) models harboring NRAS mutations (Cancer Res 2020;80(16 Suppl):Abstract nr 1951). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
FCN-159: A novel, potent and selective oral inhibitor of MEK1/2 for the treatment of solid tumors | Full reference... |