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Molecular Profile | EML4 - ALK ALK F1174I ALK G1202R |
Therapy | Lorlatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK F1174I ALK G1202R | Advanced Solid Tumor | resistant | Lorlatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing EML4-ALK with ALK G1202R and F1174I were resistant to Lorbrena (lorlatinib) in culture (PMID: 36201110). | 36201110 |
PubMed Id | Reference Title | Details |
---|---|---|
(36201110) | Prediction of Resistance Mutations Against Upcoming Anaplastic Lymphoma Kinase Inhibitors. | Full reference... |