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Molecular Profile | MAP2K1 L115P |
Therapy | Trametinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MAP2K1 L115P | Advanced Solid Tumor | resistant | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing MAP2K1 L115P were resistant to Mekinist (trametinib) in culture (PMID: 36442478). | 36442478 |
PubMed Id | Reference Title | Details |
---|---|---|
(36442478) | High-throughput functional evaluation of MAP2K1 variants in cancer. | Full reference... |