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Molecular Profile | MAP2K1 G128D |
Therapy | Trametinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MAP2K1 G128D | Advanced Solid Tumor | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, Mekinist (trametinib) inhibited viability of a transformed cell line expressing MAP2K1 G128D in culture (PMID: 36442478). | 36442478 |
MAP2K1 G128D | Advanced Solid Tumor | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, Mekinist (trametinib) inhibited Erk phosphorylation and decreased cell size in a cell line expressing MAP2K1 G128D (PMID: 34726260). | 34726260 |
PubMed Id | Reference Title | Details |
---|---|---|
(36442478) | High-throughput functional evaluation of MAP2K1 variants in cancer. | Full reference... |
(34726260) | Cutaneous epithelioid haemangiomas show somatic mutations in the mitogen-activated protein kinase pathway. | Full reference... |