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Molecular Profile | PALB2 inact mut |
Therapy | Rucaparib |
Indication/Tumor Type | biliary tract cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PALB2 inact mut | biliary tract cancer | sensitive | Rucaparib | Guideline | Actionable | Rubraca (rucaparib) is included in guidelines as second or later-line therapy for patients with biliary tract cancer harboring BRCA1/2 mutations (PMID: 36372281; ESMO.org). | detail... 36372281 |
PubMed Id | Reference Title | Details |
---|---|---|
ESMO Clinical Practice Guidelines | Full reference... | |
(36372281) | Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. | Full reference... |