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Molecular Profile | ERBB4 E715K |
Therapy | Afatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ERBB4 E715K | Advanced Solid Tumor | sensitive | Afatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Gilotrif (afatinib) inhibited growth of a transformed cell line expressing ERBB4 E715K in culture (PMID: 36860695). | 36860695 |
PubMed Id | Reference Title | Details |
---|---|---|
(36860695) | An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations. | Full reference... |