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Molecular Profile | BRAF L525R |
Therapy | Dactolisib + Selumetinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF L525R | Advanced Solid Tumor | predicted - sensitive | Dactolisib + Selumetinib | Preclinical - Cell culture | Actionable | In a preclinical study, the addition of Dactolisib (BEZ235) to treatment with Koselugo (selumetinib) resulted in increased inhibition of proliferation in Koselugo (selumetinib)-resistant cells expressing BRAF L525R compared to Dactolisib (BEZ235) alone (PMID: 36856908). | 36856908 |
PubMed Id | Reference Title | Details |
---|---|---|
(36856908) | Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant. | Full reference... |