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Molecular Profile | BRAF V600E MAP2K1 I99_K104del |
Therapy | Cobimetinib |
Indication/Tumor Type | colon adenocarcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E MAP2K1 I99_K104del | colon adenocarcinoma | resistant | Cobimetinib | Preclinical - Cell culture | Actionable | In a preclinical study, a colon adenocarcinoma cell line harboring BRAF V600E and expressing MAP2K1 I99_K104del was resistant to Cotellic (cobimetinib) in culture (PMID: 36442478). | 36442478 |
PubMed Id | Reference Title | Details |
---|---|---|
(36442478) | High-throughput functional evaluation of MAP2K1 variants in cancer. | Full reference... |