Profile Response Detail


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Molecular Profile MSH6 negative
Therapy Carboplatin + Dostarlimab-gxly + Paclitaxel
Indication/Tumor Type endometrial cancer
Response Type sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MSH6 negative endometrial cancer sensitive Carboplatin + Dostarlimab-gxly + Paclitaxel FDA approved - On Companion Diagnostic Actionable In a Phase III trial (RUBY) that supported FDA approval, Jemperli (dostarlimab-gxly) plus carboplatin and paclitaxel followed by Jemperli (dostarlimab-gxly) improved 24-month progression-free survival (61.4% vs 15.7%, HR 0.28, p<0.001) compared to placebo in patients with advanced or recurrent mismatch repair-deficient (dMMR, as indicated by a loss of MLH1, PMS2, MSH2, or MSH6 expression in an FDA-approved IHC test) or microsatellite instability-high (MSI-H) endometrial cancer (PMID: 36972026; NCT03981796). detail... 36972026 detail...
PubMed Id Reference Title Details
Full reference...
Jemperli (Dostarlimab-gxly) FDA Drug Label Full reference...
(36972026) Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer. Full reference...