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Molecular Profile | ROS1 D2113G |
Therapy | Crizotinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ROS1 D2113G | Advanced Solid Tumor | sensitive | Crizotinib | Preclinical - Cell culture | Actionable | In a preclinical study, Xalkori (crizotinib) inhibited proliferation of transformed cells expressing ROS1 D2113G in culture (PMID: 37587872). | 37587872 |
PubMed Id | Reference Title | Details |
---|---|---|
(37587872) | Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors. | Full reference... |