Profile Response Detail


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Molecular Profile HRAS G13V PIK3CA E545K
Therapy Tipifarnib
Indication/Tumor Type salivary gland carcinoma
Response Type predicted - sensitive


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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G13V PIK3CA E545K salivary gland carcinoma predicted - sensitive Tipifarnib Case Reports/Case Series Actionable In a clinical case study, Zarnestra (tipifarnib) treatment resulted in a partial response and progression-free survival lasting more than 5 months in a patient with androgen-receptor (AR)-positive salivary duct carcinoma harboring HRAS G13V and PIK3CA E545K (PMID: 37427101). 37427101
PubMed Id Reference Title Details
(37427101) Targeted treatment in a case series of AR+, HRAS/PIK3CA co-mutated salivary duct carcinoma. Full reference...