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Molecular Profile | APC inact mut |
Therapy | PKF118-310 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC inact mut | colorectal cancer | sensitive | PKF118-310 | Preclinical | Actionable | In a preclinical study, PKF118-310 inhibited proliferation of colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). | 14749129 |
PubMed Id | Reference Title | Details |
---|---|---|
(14749129) | Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. | Full reference... |