Therapy Detail

Therapy Name PKF118-310
Therapy Description

PKF118-310 inhibits KDM4A activity (PMID: 27767379) and the CTNNB1/TCF interaction, which results in apoptosis and anti-tumor activity (PMID: 19662654).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PKF118-310 CTNNB1 Inhibitor 26 KDM4 Inhibitor 2 PKF118-310 inhibits KDM4A activity (PMID: 27767379) and the CTNNB1/TCF interaction, which results in apoptosis and anti-tumor activity (PMID: 19662654).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown gastrointestinal stromal tumor not applicable PKF118-310 Preclinical - Cell line xenograft Actionable In a preclinical study, PKF118-310 decreased viability of gastrointestinal stromal tumor (GIST) cell lines in culture, and reduced tumor growth in xenograft models (PMID: 28611108). 28611108
APC inact mut colorectal cancer sensitive PKF118-310 Preclinical Actionable In a preclinical study, PKF118-310 inhibited proliferation of colorectal cancer cell line harboring an APC inactivating mutation in culture (PMID: 14749129). 14749129
Clinical Trial Phase Therapies Title Recruitment Status