Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Molecular Profile | NRAS mutant |
Therapy | Navitoclax + Trametinib |
Indication/Tumor Type | female reproductive organ cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS mutant | female reproductive organ cancer | predicted - sensitive | Navitoclax + Trametinib | Phase Ib/II | Actionable | In a Phase I/II trial, treatment with the combination of Navitoclax (ABT-263) and Mekinist (trametinib) resulted in a partial response rate of 33.3% (7/21), a disease control rate of 85.7%, and a median duration of response of 8.2 months in patients with gynecologic cancers harboring mutations in NRAS or KRAS (Ann Oncol 34 (2023): S467; NCT02079740). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
664P Final results of a phase I/II study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors | Full reference... |