Disease Detail


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Name female reproductive organ cancer
Definition A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva.
Source DiseaseOntology.org
Alt Ids DOID:1244 DOID:1281
Path disease disease of cellular proliferation cancer organ system cancer reproductive organ cancer female reproductive organ cancer


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PIK3CA mutant Capivasertib female reproductive organ cancer predicted - sensitive detail...
BRAF D594N Trametinib female reproductive organ cancer no benefit detail...
BRAF N581S Trametinib female reproductive organ cancer no benefit detail...
NRAS mutant Navitoclax + Trametinib female reproductive organ cancer predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00800345 Phase I Pazopanib + Topotecan Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic Tumors Completed USA 0
NCT01831089 Phase I Bevacizumab + Lurbinectedin + Paclitaxel Lurbinectedin + Paclitaxel Phase I Study of Lurbinectedin (PM01183) in Combination With Paclitaxel, With or Without Bevacizumab, in Selected Advanced Solid Tumors Completed USA | ESP 1
NCT03073525 Phase II Atezolizumab + FANG vaccine Trial of Atezolizumab and Vigil for Advanced Gynecological Cancers (A Companion Study to CL-PTL-119) Completed USA 0
NCT03277482 Phase I Durvalumab + Tremelimumab Durvalumab Durvalumab, Tremelimumab + Radiotherapy in Gynecologic Cancer Terminated USA 0
NCT04042116 Phase Ib/II Lucitanib + Nivolumab A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor Suspended USA | ITA | ESP | DEU | BEL | AUT 0
NCT04273061 Phase II Atezolizumab Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity (CAPTIV-8) Recruiting CAN 0
NCT04395079 Phase II Tremelimumab Durvalumab Brachytherapy With Durvalumab or Tremelimumab for the Treatment of Patients With Platinum-Resistant, Refractory, Recurrent, or Metastatic Gynecological Malignancies Active, not recruiting USA 0
NCT04682431 Phase I Pembrolizumab + PY159 PY159 A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors Active, not recruiting USA 0
NCT05238922 Phase I INCB123667 Study of INCB123667 in Subjects With Advanced Solid Tumors Recruiting USA | ITA | GBR | FRA 3
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib Recruiting USA 0
NCT05636215 Phase Ib/II Orismilast A First-in-human Study of IBI354 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors Not yet recruiting AUS 0
NCT05704985 Phase I DK210 DK210 + Nivolumab Paclitaxel DK210 + Pembrolizumab Oxaliplatin Capecitabine Fluorouracil Carboplatin Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors Recruiting USA 0
NCT05768139 Phase Ib/II Fulvestrant + STX-478 STX-478 First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors Recruiting USA 0
NCT05787561 Phase II Defactinib + RO5126766 A Study of VS-6766 and Defactinib in People With Mesonephric Gynecologic Cancer Recruiting USA 0