Therapy Detail

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Therapy Name STX-478
Synonyms
Therapy Description

STX-478 inhibits PIK3CA H1047 mutations, potentially resulting in decreased tumor cell proliferation and reduced tumor growth (Cancer Res 2023;83(5 Suppl):Abstract nr P4-07-04).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
STX-478 STX 478|STX478 PIK3CA inhibitor 23 STX-478 inhibits PIK3CA H1047 mutations, potentially resulting in decreased tumor cell proliferation and reduced tumor growth (Cancer Res 2023;83(5 Suppl):Abstract nr P4-07-04).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047R head and neck squamous cell carcinoma sensitive STX-478 Preclinical - Cell line xenograft Actionable In a preclinical study, STX-478 inhibited viability in head and neck squamous cell cancer cell lines harboring PIK3CA H1047R in culture, and inhibited tumor growth and induced tumor regression in a cell line xenograft model (PMID: 37623743). 37623743
PIK3CA K111R PIK3CA H1047R lung carcinoma sensitive STX-478 Preclinical - Cell line xenograft Actionable In a preclinical study, STX-478 inhibited viability in a lung carcinoma cell line harboring PIK3CA H1047R and K111R in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37623743). 37623743
PIK3CA E545K head and neck squamous cell carcinoma sensitive STX-478 Preclinical - Pdx Actionable In a preclinical study, STX-478 inhibited tumor growth of a head and neck squamous cell cancer patient-derived xenograft (PDX) model harboring PIK3CA E545K (PMID: 37623743). 37623743
PIK3CA H1047R Her2-receptor positive breast cancer sensitive STX-478 Preclinical - Cell line xenograft Actionable In a preclinical study, STX-478 inhibited viability in a hormone receptor-negative, ERBB2 (HER2)-positive breast cancer cell line harboring PIK3CA H1047R in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 37623743). 37623743
PIK3CA P539R PIK3CA H1047R Advanced Solid Tumor sensitive STX-478 Preclinical - Cell culture Actionable In a preclinical study, STX-478 inhibited viability of a cell line harboring PIK3CA H1047R and P539R in culture (PMID: 37623743). 37623743
PIK3CA H1047L colon cancer sensitive STX-478 Preclinical - Cell line xenograft Actionable In a preclinical study, STX-478 inhibited viability in a colon cancer cell line harboring PIK3CA H1047L in culture, and inhibited tumor growth and induced tumor regression in a cell line xenograft model (PMID: 37623743). 37623743
PIK3CA E542K Her2-receptor positive breast cancer sensitive STX-478 Preclinical - Pdx Actionable In a preclinical study, STX-478 inhibited tumor growth of a ERBB2 (HER2)-positive breast cancer patient-derived xenograft (PDX) model harboring PIK3CA E542K (PMID: 37623743). 37623743
PIK3CA H1047R Her2-receptor negative breast cancer sensitive STX-478 Preclinical - Pdx & cell culture Actionable In a preclinical study, STX-478 inhibited viability in an ESR1-positive, ERBB2 (HER2)-negative breast cancer cell line harboring PIK3CA H1047R in culture and inhibited tumor growth and induced tumor regression with high-dose STX-478 in a cell line xenograft model and inhibited tumor growth in a patient-derived xenograft (PDX) model (PMID: 37623743). 37623743
PIK3CA D350N PIK3CA H1047R Advanced Solid Tumor sensitive STX-478 Preclinical - Cell culture Actionable In a preclinical study, STX-478 inhibited viability of a cell line harboring PIK3CA H1047R and D350N in culture (PMID: 37623743). 37623743
PIK3CA E542K PIK3CA H1065L breast cancer sensitive STX-478 Preclinical - Pdx Actionable In a preclinical study, STX-478 inhibited tumor growth of a breast cancer patient-derived xenograft (PDX) model harboring PIK3CA E542K and H1065L (PMID: 37623743). 37623743

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05768139 Phase Ib/II Fulvestrant + STX-478 STX-478 First-in-Human Study of STX-478 as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors Recruiting USA | ITA | FRA | ESP 0


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