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Molecular Profile EML4 - ALK
Therapy Alectinib + Zoledronic acid
Indication/Tumor Type large cell neuroendocrine carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK large cell neuroendocrine carcinoma predicted - sensitive Alectinib + Zoledronic acid Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Alecensa (alectinib) and Zoledronic acid resulted in a partial response with progression-free survival ongoing at 21 months in a patient with metastatic large cell neuroendocrine carcinoma harboring EML4-ALK (e6:e20) (PMID: 38023218). 38023218
PubMed Id Reference Title Details
(38023218) Two case reports: EML4-ALK rearrangement large cell neuroendocrine carcinoma and literature review. Full reference...