Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
EML4 - ALK Alectinib large cell neuroendocrine carcinoma predicted - sensitive detail...
EML4 - ALK ALK V1180L ALK G1202R Alectinib large cell neuroendocrine carcinoma predicted - resistant detail...
EML4 - ALK ALK V1180L ALK G1202R Brigatinib large cell neuroendocrine carcinoma predicted - resistant detail...
EML4 - ALK ALK V1180L ALK G1202R Lorlatinib large cell neuroendocrine carcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02936323 Phase Ib/II PEN-221 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Completed USA 1
NCT03901378 Phase II Carboplatin + Etoposide + Pembrolizumab Pembrolizumab Cisplatin + Etoposide + Pembrolizumab Pembrolizumab With Chemotherapy in Metastatic or Unresectable High Grade Gastroenteropancreatic or Lung Neuroendocrine Carcinoma Withdrawn USA 0
NCT04079712 Phase II Cabozantinib + Ipilimumab + Nivolumab Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors Active, not recruiting USA | CAN 0
NCT04427787 Phase II Cabozantinib + Lanreotide acetate A Trial Aiming to Assess the Safety and Activity of the Combination of Cabozantinib Plus Lanreotide in GEP and NET (LOLA) Recruiting ITA 0
NCT04429087 Phase I BI 764532 A Study to Test Different Doses of BI 764532 in Patients With Small Cell Lung Cancer and Other Neuroendocrine Tumours That Are Positive for Delta-Like Ligand 3 (DLL3). Recruiting USA | ESP | DEU 1