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Molecular Profile BRAF V600E
Therapy Vemurafenib
Indication/Tumor Type ameloblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E ameloblastoma sensitive Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, Zelboraf (vemurafenib) inhibited viability of an ameloblastoma cell line harboring BRAF V600E in culture (PMID: 24859340). 24859340
BRAF V600E ameloblastoma sensitive Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, Zelboraf (vemurafenib) inhibited viability of ameloblastoma cell lines harboring BRAF V600E in culture (PMID: 35689405). 35689405
PubMed Id Reference Title Details
(24859340) Identification of recurrent SMO and BRAF mutations in ameloblastomas. Full reference...
(35689405) New Ameloblastoma Cell Lines Enable Preclinical Study of Targeted Therapies. Full reference...