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Molecular Profile | ATM inact mut |
Therapy | Radiotherapy + RP-3500 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM inact mut | Advanced Solid Tumor | predicted - sensitive | Radiotherapy + RP-3500 | Case Reports/Case Series | Actionable | In a Phase I trial, the addition of RP-3500 to radiotherapy treatment resulted in metabolic complete responses in two patients with advanced solid tumors harboring ATM inactivating mutations (Cancer Res (2024) 84 (1_Supplement): A002, NCT05566574). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract A002: Genotype-directed synthetic cytotoxicity of ATR inhibition with radiotherapy | Full reference... |