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Molecular Profile | NRAS mutant |
Therapy | IK-595 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS mutant | Advanced Solid Tumor | predicted - sensitive | IK-595 | Preclinical | Actionable | In a preclinical study, IK-595 inhibited Mek and Erk phosphorylation and decreased tumor growth in an NRAS-mutant mouse tumor model (Mol Cancer Res (2023) 21 (5_Supplement): PR10). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract PR10: IK-595, a MEK-RAF complex inhibitor, obviates CRAF mediated resistance resulting in superior RAS/MAPK pathway inhibition and anti-tumor activity in RAS/RAF altered cancers | Full reference... |