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Molecular Profile | BRAF V600E |
Therapy | Tunlametinib + Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | melanoma | sensitive | Tunlametinib + Vemurafenib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with the combination of Tunlametinib (HL-085) and Zelboraf (vemurafenib) synergistically inhibited proliferation of a melanoma cell line harboring BRAF V600E in culture, and synergistically inhibited tumor growth in a cell line xenograft model (PMID: 37808191). | 37808191 |
PubMed Id | Reference Title | Details |
---|---|---|
(37808191) | Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor. | Full reference... |