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Molecular Profile | BRAF A598_T599insV |
Therapy | Dabrafenib |
Indication/Tumor Type | pilocytic astrocytoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF A598_T599insV | pilocytic astrocytoma | predicted - sensitive | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, Tafinlar (dabrafenib) resulted in neurological improvement and decreased tumor size after 3 months of treatment in a pediatric patient with pilocytic astrocytoma harboring BRAF A598_T599insV (reported as BRAF V599ins) (PMID: 38781546). | 38781546 |
PubMed Id | Reference Title | Details |
---|---|---|
(38781546) | Dabrafenib for Pilocytic Astrocytoma With BRAF V599ins. | Full reference... |