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ID DOID:4851
Name pilocytic astrocytoma
Definition A childhood low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma childhood low-grade glioma pilocytic astrocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib pilocytic astrocytoma predicted - sensitive detail...
BRAF V600D Dabrafenib + Trametinib pilocytic astrocytoma predicted - sensitive detail...
BRAF fusion N/A pilocytic astrocytoma not applicable detail...
BRAF V600E Dabrafenib + Trametinib pilocytic astrocytoma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib pilocytic astrocytoma sensitive detail...
BRAF V600E Selumetinib pilocytic astrocytoma sensitive detail...
BRAF fusion Selumetinib pilocytic astrocytoma sensitive detail...
BRAF V600E Vemurafenib pilocytic astrocytoma predicted - sensitive detail...
FGFR1 N546K Pemigatinib pilocytic astrocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01089101 Phase Ib/II Selumetinib Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Active, not recruiting USA 0
NCT01734512 Phase II Everolimus PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Active, not recruiting USA 0
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting USA 0
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS 9
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04923126 Phase Ib/II PD-0325901 SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05267106 Phase II Pemigatinib Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209) Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU 2
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN 2