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ID DOID:4851
Name pilocytic astrocytoma
Definition An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer pilocytic astrocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib pilocytic astrocytoma predicted - sensitive detail...
BRAF V600D Dabrafenib + Trametinib pilocytic astrocytoma predicted - sensitive detail...
BRAF fusion N/A pilocytic astrocytoma not applicable detail...
BRAF V600E Dabrafenib + Trametinib pilocytic astrocytoma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib pilocytic astrocytoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01089101 Phase Ib/II Selumetinib Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting
NCT01734512 Phase II Everolimus PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Active, not recruiting
NCT01837862 Phase Ib/II Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed
NCT03975829 FDA approved Dabrafenib + Trametinib Pediatric Long-Term Follow-up and Rollover Study Recruiting