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ID | DOID:4851 |
Name | pilocytic astrocytoma |
Definition | A pediatric low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer cell type cancer malignant glioma low-grade glioma pediatric low-grade glioma pilocytic astrocytoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
BRAF V600E | Dabrafenib | pilocytic astrocytoma | predicted - sensitive | detail... |
BRAF V600D | Dabrafenib + Trametinib | pilocytic astrocytoma | predicted - sensitive | detail... |
BRAF fusion | N/A | pilocytic astrocytoma | not applicable | detail... |
BRAF V600E | Dabrafenib + Trametinib | pilocytic astrocytoma | sensitive | detail... |
BRAF V600E | Cobimetinib + Vemurafenib | pilocytic astrocytoma | sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01089101 | Phase Ib/II | Selumetinib | Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma | Active, not recruiting | USA | 0 |
NCT01734512 | Phase II | Everolimus | PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children | Active, not recruiting | USA | 0 |
NCT01837862 | Phase Ib/II | Carboplatin + Mebendazole + Temozolomide + Vincristine Sulfate Bevacizumab + Irinotecan + Mebendazole | A Phase I/II Study of Mebendazole for the Treatment of Pediatric Gliomas | Unknown status | USA | 0 |
NCT01999270 | Phase I | Bevacizumab + Irinotecan | Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors | Completed | USA | 0 |
NCT03975829 | FDA approved | Dabrafenib + Trametinib | Pediatric Long-Term Follow-up and Rollover Study | Recruiting | USA | 3 |
NCT04541082 | Phase I | ONC206 | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | Recruiting | USA | 0 |