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Molecular Profile | BRAF V600E |
Therapy | Dabrafenib |
Indication/Tumor Type | pilocytic astrocytoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | pilocytic astrocytoma | predicted - sensitive | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, Tafinlar (dabrafenib) treatment resulted in a near complete response and resolution of leptomeningeal dissemination in a patient with pilocytic astrocytoma harboring BRAF V600E (PMID: 28784858). | 28784858 |
PubMed Id | Reference Title | Details |
---|---|---|
(28784858) | Targeted MAPK Pathway Inhibitors in Patients With Disseminated Pilocytic Astrocytomas. | Full reference... |