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ID | DOID:80829 |
Name | low grade glioma |
Definition | A cell type benign neoplasm that has_material_basis_in glial cells (astrocytes, oligodendrocytes or ependymocytes). |
Source | DiseaseOntology.org |
Alt Ids | DOID:0060101 |
Path | disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
BRAF V600X | Dabrafenib | low grade glioma | predicted - sensitive | detail... |
IDH1 R132H | Ivosidenib | low grade glioma | predicted - sensitive | detail... |
IDH1 R132X | Ivosidenib | low grade glioma | predicted - sensitive | detail... |
NTRK1 fusion | Larotrectinib | low grade glioma | sensitive | detail... |
NTRK2 fusion | Larotrectinib | low grade glioma | sensitive | detail... |
NTRK2 fusion | Entrectinib | low grade glioma | sensitive | detail... |
NTRK1 fusion | Entrectinib | low grade glioma | sensitive | detail... |
BRAF V600E | Dabrafenib + Trametinib | low grade glioma | sensitive | detail... |
BRAF V600E | Cobimetinib + Vemurafenib | low grade glioma | sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT03585465 | Phase Ib/II | Capecitabine + Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Cyclophosphamide + Vinblastine Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Nivolumab | Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors | Recruiting | FRA | BEL | 0 |
NCT04283669 | Phase II | Crizotinib | Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas (NF110) | Active, not recruiting | USA | 0 |
NCT04374305 | Phase II | Brigatinib | Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) | Recruiting | USA | 0 |
NCT04576117 | Phase III | Selumetinib Selumetinib + Vinblastine | A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma | Recruiting | USA | CAN | 0 |
NCT04773782 | Phase Ib/II | Avapritinib | A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling | Recruiting | USA | DEU | CAN | AUT | 1 |
NCT04775485 | Phase II | MLN2480 | A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma (FIREFLY-1) | Recruiting | USA | DEU | CAN | 8 |
NCT04923126 | Phase Ib/II | PD-0325901 | SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma | Recruiting | USA | 0 |
NCT05076513 | Phase I | Niraparib | Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma | Recruiting | USA | 0 |
NCT05180825 | Phase II | Vinblastine Trametinib | Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC) | Recruiting | FRA | 0 |
NCT05188508 | Phase II | Olaparib + Pembrolizumab + Temozolomide | Pembrolizumab, Olaparib, and Temozolomide for People With Glioma | Recruiting | USA | 0 |
NCT05222165 | Phase Ib/II | Infigratinib | Study With Infigratinib in Subjects With Advanced Solid and CNS Tumors or Recurrent or Progressive Low-Grade Glioma With Selected FGFR1-3 Alterations (NEWEL) | Not yet recruiting | USA | DEU | CAN | 0 |
NCT05345002 | Phase II | Retifanlimab + Tretinoin | All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma | Not yet recruiting | USA | 0 |
NCT05406700 | Phase I | Niraparib | Niraparib In Recurrent LDH 1/2 Gliomas | Not yet recruiting | USA | 0 |