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ID DOID:80829
Name low grade glioma
Definition A cell type benign neoplasm that has_material_basis_in glial cells (astrocytes, oligodendrocytes or ependymocytes).
Source DiseaseOntology.org
Alt Ids DOID:0060101
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600X Dabrafenib low grade glioma predicted - sensitive detail...
IDH1 R132H Ivosidenib low grade glioma predicted - sensitive detail...
IDH1 R132X Ivosidenib low grade glioma predicted - sensitive detail...
NTRK1 fusion Larotrectinib low grade glioma sensitive detail...
NTRK2 fusion Larotrectinib low grade glioma sensitive detail...
NTRK2 fusion Entrectinib low grade glioma sensitive detail...
NTRK1 fusion Entrectinib low grade glioma sensitive detail...
BRAF V600E Dabrafenib + Trametinib low grade glioma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib low grade glioma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03585465 Phase Ib/II Capecitabine + Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Cyclophosphamide + Vinblastine Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Nivolumab Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors Recruiting FRA | BEL 0
NCT04283669 Phase II Crizotinib Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas (NF110) Active, not recruiting USA 0
NCT04374305 Phase II Brigatinib Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) Recruiting USA 0
NCT04576117 Phase III Selumetinib Selumetinib + Vinblastine A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma Recruiting USA | CAN 0
NCT04773782 Phase Ib/II Avapritinib A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling Recruiting USA | DEU | CAN | AUT 1
NCT04775485 Phase II MLN2480 A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma (FIREFLY-1) Recruiting USA | DEU | CAN 8
NCT04923126 Phase Ib/II PD-0325901 SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05076513 Phase I Niraparib Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma Recruiting USA 0
NCT05180825 Phase II Vinblastine Trametinib Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC) Recruiting FRA 0
NCT05188508 Phase II Olaparib + Pembrolizumab + Temozolomide Pembrolizumab, Olaparib, and Temozolomide for People With Glioma Recruiting USA 0
NCT05222165 Phase Ib/II Infigratinib Study With Infigratinib in Subjects With Advanced Solid and CNS Tumors or Recurrent or Progressive Low-Grade Glioma With Selected FGFR1-3 Alterations (NEWEL) Not yet recruiting USA | DEU | CAN 0
NCT05345002 Phase II Retifanlimab + Tretinoin All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma Not yet recruiting USA 0
NCT05406700 Phase I Niraparib Niraparib In Recurrent LDH 1/2 Gliomas Not yet recruiting USA 0