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ID DOID:80829
Name low grade glioma
Definition A cell type benign neoplasm that has_material_basis_in glial cells (astrocytes, oligodendrocytes or ependymocytes).
Source DiseaseOntology.org
Alt Ids DOID:0060101
Path disease disease of cellular proliferation benign neoplasm cell type benign neoplasm low grade glioma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600X Dabrafenib low grade glioma predicted - sensitive detail...
IDH1 R132H Ivosidenib low grade glioma predicted - sensitive detail...
IDH1 R132X Ivosidenib low grade glioma predicted - sensitive detail...
BRAF V600E Dabrafenib + Trametinib low grade glioma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib low grade glioma sensitive detail...
BRAF fusion Ulixertinib low grade glioma predicted - sensitive detail...
BRAF V600X Trametinib low grade glioma predicted - sensitive detail...
BRAF V600X Dabrafenib + Trametinib low grade glioma predicted - sensitive detail...
FGFR1 act mut Erdafitinib low grade glioma predicted - sensitive detail...
FGFR1 K656E Erdafitinib low grade glioma predicted - sensitive detail...
BRAF V600E FCN-159 low grade glioma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03585465 Phase Ib/II Capecitabine + Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Cyclophosphamide + Vinblastine Cyclophosphamide + Nivolumab + Vinblastine Capecitabine + Nivolumab Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors Active, not recruiting FRA | BEL 0
NCT04283669 Phase II Crizotinib Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas (NF110) Active, not recruiting USA 0
NCT04374305 Phase II Brigatinib Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2) (INTUITT-NF2) Recruiting USA 0
NCT04485559 Phase I Everolimus + Trametinib Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) Recruiting USA 0
NCT04576117 Phase III Selumetinib Selumetinib + Vinblastine A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma Recruiting USA | CAN 0
NCT04773782 Phase Ib/II Avapritinib A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling Recruiting USA | ITA | GBR | FRA | DEU | CAN | AUT | AUS 1
NCT04775485 Phase II Tovorafenib A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors (FIREFLY-1) Recruiting USA | NLD | GBR | DEU | CAN | AUS 5
NCT04923126 Phase Ib/II PD-0325901 SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma Recruiting USA 0
NCT05076513 Phase I Niraparib Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma Recruiting USA 0
NCT05180825 Phase II Vinblastine Trametinib Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy (PLGG - MEKTRIC) Recruiting FRA 0
NCT05188508 Phase II Olaparib + Pembrolizumab + Temozolomide Pembrolizumab, Olaparib, and Temozolomide for People With Glioma Recruiting USA 0
NCT05222165 Phase Ib/II Infigratinib Study With Infigratinib in Subjects With Advanced Solid and CNS Tumors or Recurrent or Progressive Low-Grade Glioma With Selected FGFR1-3 Alterations (NEWEL) Withdrawn USA | DEU | CAN 0
NCT05303519 Phase II DS-1001b Safusidenib Phase 2 Study in IDH1 Mutant Glioma Recruiting USA 0
NCT05345002 Phase II Retifanlimab + Tretinoin All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma Recruiting USA 0
NCT05406700 Phase I Niraparib Niraparib In Recurrent IDH 1/2 Gliomas Recruiting USA 0
NCT05566795 Phase III Tovorafenib DAY101 vs. Standard of Care Chemotherapy in Pediatric Patients With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2) Recruiting USA | NZL | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 13
NCT05577416 Phase I DS-1001b A Study of AB-218 in Patients With IDH1 Mutated Low Grade Glioma (AB-218-IIT-201) Active, not recruiting AUS 0
NCT05804227 Phase I Ulixertinib Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Low-Grade Gliomas in Adults Recruiting USA 0
NCT06104488 Phase I RO5126766 A Study of Avutometinib for People With Solid Tumor Cancers Recruiting USA 0
NCT06258018 Phase Ib/II Niraparib + Temozolomide Niraparib and Temozolomide in Patients Glioblastoma (ONC-2022-001) Not yet recruiting ITA 0
NCT06381570 Phase I Tovorafenib + Vinblastine Tovorafenib Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas (VICTORY) Recruiting CAN 0