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Molecular Profile | JAK2 V617F |
Therapy | Flonoltinib maleate |
Indication/Tumor Type | myeloproliferative neoplasm |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | myeloproliferative neoplasm | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and colony formation in myeloproliferative neoplasm patient-derived cells harboring JAK2 V617F in culture (PMID: 35256594). | 35256594 |
PubMed Id | Reference Title | Details |
---|---|---|
(35256594) | Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms. | Full reference... |