Therapy Detail

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Therapy Name Flonoltinib maleate
Synonyms
Therapy Description

Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Flonoltinib maleate FLT3 Inhibitor 69 JAK2 Inhibitor 19 Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F myelofibrosis sensitive Flonoltinib maleate Preclinical Actionable In a preclinical study, Flonoltinib maleate decreased splenomegaly and improved survival in a mouse model of myelofibrosis harboring JAK2 V617F (PMID: 35256594). 35256594
FLT3 exon 14 ins FLT3 D835V hematologic cancer sensitive Flonoltinib maleate Preclinical - Cell culture Actionable In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD and FLT3 D835V in culture (PMID: 35256594). 35256594
JAK2 V617F hematologic cancer sensitive Flonoltinib maleate Preclinical Actionable In a preclinical study, Flonoltinib maleate inhibited Jak2 downstream signaling and proliferation and induced apoptosis in a cell line expressing JAK2 V617F in culture and increased survival in a mouse model (PMID: 35256594). 35256594
JAK2 V617F myeloproliferative neoplasm sensitive Flonoltinib maleate Preclinical - Cell culture Actionable In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and colony formation in myeloproliferative neoplasm patient-derived cells harboring JAK2 V617F in culture (PMID: 35256594). 35256594
JAK2 V617F acute myeloid leukemia sensitive Flonoltinib maleate Preclinical - Cell culture Actionable In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and cell cycle progression and induced apoptosis in an acute myeloid leukemia cell line harboring JAK2 V617F in culture (PMID: 35256594). 35256594
FLT3 exon 14 ins acute myeloid leukemia sensitive Flonoltinib maleate Preclinical - Cell culture Actionable In a preclinical study, Flonoltinib maleate inhibited Flt3 pathway signaling and cell cycle progression and induced apoptosis in acute myeloid leukemia cells harboring a FLT3-ITD in culture (PMID: 35256594). 35256594
FLT3 exon 14 ins hematologic cancer sensitive Flonoltinib maleate Preclinical - Cell culture Actionable In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD in culture (PMID: 35256594). 35256594

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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