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ID DOID:4971
Name myelofibrosis
Definition A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue.
Source DiseaseOntology.org
Alt Ids DOID:5737
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer bone marrow cancer myeloid neoplasm myelofibrosis

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
MPL W515L Everolimus myelofibrosis sensitive detail...
MPL W515K Everolimus myelofibrosis sensitive detail...
Unknown unknown Ruxolitinib myelofibrosis not applicable detail...
MPL W515L MK2206 myelofibrosis sensitive detail...
MPL W515L CHZ868 myelofibrosis sensitive detail...
Unknown unknown Fedratinib myelofibrosis not applicable detail...
Unknown unknown XL019 myelofibrosis not applicable detail...
CALR L367fs Fedratinib myelofibrosis predicted - sensitive detail...
JAK2 V617F N/A myelofibrosis not applicable detail...
MPL W515L N/A myelofibrosis not applicable detail...
MPL W515K N/A myelofibrosis not applicable detail...
CALR mutant N/A myelofibrosis not applicable detail...
CALR L367fs N/A myelofibrosis not applicable detail...
CALR wild-type JAK2 wild-type MPL wild-type N/A myelofibrosis not applicable detail...
ASXL1 mutant N/A myelofibrosis not applicable detail...
EZH2 mutant N/A myelofibrosis not applicable detail...
IDH1 mutant N/A myelofibrosis not applicable detail...
IDH2 mutant N/A myelofibrosis not applicable detail...
SRSF2 mutant N/A myelofibrosis not applicable detail...
ASXL1 wild-type CALR mut N/A myelofibrosis not applicable detail...
ASXL1 mut CALR wild-type N/A myelofibrosis not applicable detail...
ASXL1 mut CALR mut N/A myelofibrosis not applicable detail...
U2AF1 Q157X N/A myelofibrosis not applicable detail...
U2AF1 mutant N/A myelofibrosis not applicable detail...
DNMT3A mutant N/A myelofibrosis not applicable detail...
CBL mutant N/A myelofibrosis not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01398462 Phase I CWP232291 Phase I Clinical Study of CWP232291 in Acute Myeloid Leukemia Patients Completed
NCT01787487 Phase II Azacitidine + Ruxolitinib Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm Recruiting
NCT02098161 Phase II LCL161 LCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis Active, not recruiting
NCT02158858 Phase Ib/II CPI-0610 + Ruxolitinib CPI-0610 A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis Recruiting
NCT02251821 Phase II Fludarabine Tacrolimus Mycophenolate mofetil Busulfan Pacritinib Momelotinib Melphalan Methotrexate Ruxolitinib Cyclophosphamide JAK-2 Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis Recruiting
NCT02268253 Phase II tagraxofusp-erzs Tagraxofusp (SL-401) in Patients With CMML or MF Recruiting
NCT02421354 Phase II Nivolumab Study of Nivolumab in Patients With Myelofibrosis Terminated
NCT02440685 Phase Ib/II ASN002 A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid Tumors Terminated
NCT02493530 Phase I Ruxolitinib + Umbralisib TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea Active, not recruiting
NCT02528877 Phase I Fludarabine + Melphalan Ruxolitinib + Sirolimus + Tacrolimus Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis Withdrawn
NCT02530034 Phase I Hu8F4 Hu8F4 in Treating Patients With Advanced Hematologic Malignancies Recruiting
NCT02530619 Phase I Alisertib Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia Unknown status
NCT02564536 Phase I Decitabine + Pacritinib Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS) Withdrawn
NCT02718300 Phase II Parsaclisib + Ruxolitinib A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis Recruiting
NCT02966353 Phase II Ruxolitinib Efficacy and Safety of Ruxolitinib in the Treatment of Anemic Myelofibrosis Patients. (REALISE) Completed
NCT03042689 Phase I Regorafenib Study of Regorafenib in Patients With Advanced Myeloid Malignancies Recruiting
NCT03065400 Phase II Pembrolizumab PD-1 Inhibition in Advanced Myeloproliferative Neoplasms Completed
NCT03136185 Phase II IMG-7289 IMG-7289 in Patients With Myelofibrosis Recruiting
NCT03144687 Phase II Itacitinib + Ruxolitinib Itacitinib A Study of Itacitinib in Combination With Low-Dose Ruxolitinib or Itacitinib Alone Following Ruxolitinib in Subjects With Myelofibrosis Active, not recruiting
NCT03165734 Phase II Lenalidomide Ruxolitinib Hydroxyurea Pacritinib Thalidomide A Phase 2/3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis (PACIFICA) Recruiting
NCT03289910 Phase II Carboplatin + Topotecan + Veliparib Carboplatin + Topotecan Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia Recruiting
NCT03326310 Phase I Azacitidine + Selumetinib Study of MEK Inhibitor Selumetinib in Combination With Azacitidine in Patients With Higher Risk Chronic Myeloid Neoplasia Recruiting
NCT03373877 Phase I PU-H71 + Ruxolitinib Evaluation of Ruxolitinib in Combination With PU-H71 for Treatment of Myelofibrosis Active, not recruiting
NCT03480360 Phase III Cyclophosphamide + Fludarabine Filgrastim + Mycophenolate mofetil + Tacrolimus Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression Recruiting
NCT03592576 Expanded access Navitoclax Expanded Access to Navitoclax Available
NCT03627403 Phase II Selinexor Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors (ESSENTIAL) Recruiting
NCT03662126 Phase II KRT-232 KRT-232 in Subjects With PMF, Post-PV MF, or Post-ET MF Who Have Failed a JAK Inhibitor Recruiting
NCT03755518 Phase III Fedratinib An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib (FREEDOM) Recruiting
NCT03862157 Phase Ib/II Azacitidine + MLN4924 + Venetoclax Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Recruiting
NCT03886831 Phase I PRT543 A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies Recruiting
NCT03895112 Phase I AVID200 MPN-RC 118 AVID200 in Myelofibrosis Recruiting
NCT03912064 Phase I Ipilimumab A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT Recruiting
NCT03935555 Phase I PU-H71 Assess the Safety, Tolerability Oral PU-H71 in Subjects Taking Ruxolitinib Recruiting
NCT04089449 Phase I PRT811 A Study of PRT811 in Participants With Advanced Solid Tumors, Gliomas and Myelofibrosis Recruiting
NCT04173494 Phase III Danazol Momelotinib A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Patients (MOMENTUM) Recruiting
NCT04176198 Phase I TP-3654 A Study of Oral TP-3654 in Patients With Myelofibrosis Recruiting
NCT04279847 Phase I INCB057643 Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis Not yet recruiting
NCT04281498 Phase II Enasidenib + Ruxolitinib Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation Not yet recruiting
NCT04282187 Phase II Decitabine + Fedratinib Decitabine + Ruxolitinib Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms Recruiting
NCT04454658 Phase I ABBV-744 ABBV-744 + Navitoclax ABBV-744 + Ruxolitinib Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis Not yet recruiting
NCT04472598 Phase III Ruxolitinib Navitoclax + Ruxolitinib Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis (TRANSFORM-1) Not yet recruiting
NCT04480086 Phase I Mivebresib + Navitoclax Mivebresib + Ruxolitinib Mivebresib Safety and Tolerability Study of Mivebresib Tablet Alone or in Combination With Ruxolitinib Tablet or Navitoclax Tablet in Adult Participants With Myelofibrosis Not yet recruiting