Therapy Detail

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Therapy Name Canakinumab
Synonyms
Therapy Description

Ilaris (canakinumab) is a monoclonal antibody against interleukin-1beta, which has anti-inflammatory activity and may decrease tumor progression (PMID: 28855077).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Canakinumab Ilaris ACZ-885 Ilaris (canakinumab) is a monoclonal antibody against interleukin-1beta, which has anti-inflammatory activity and may decrease tumor progression (PMID: 28855077).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03968419 Phase II Canakinumab Pembrolizumab Canakinumab + Pembrolizumab This Study Will Evaluate the Effect of Canakinumab or Pembrolizumab Given as Monotherapy or in Combination as Neo-adjuvant Treatment for Subjects With Early Stages NSCLC. (CANOPY-N) Terminated USA | NLD | FRA | ESP | DEU | CAN | BEL 5
NCT02900664 Phase I Nazartinib + Spartalizumab CJM112 + Spartalizumab Spartalizumab + Trametinib Canakinumab + Spartalizumab Canakinumab A Study of PDR001 in Combination With CJM112, EGF816, Ilaris (Canakinumab) or Mekinist (Trametinib) Completed USA | ITA | FRA | ESP | CAN | BEL 3
NCT05467800 Phase II Canakinumab Study of Canakinumab in Patients With Myelofibrosis Recruiting USA 0
NCT03447769 Phase III Canakinumab Brief Title: Study of Efficacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects With Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: (None) Terminated USA | ITA | GBR | FRA | ESP | DEU | CAN | AUT 33
NCT04810611 Phase I NIS793 Sabatolimab Canakinumab + Sabatolimab NIS793 + Sabatolimab Canakinumab Phase Ib Study of Select Drug Combinations in Patients With Lower Risk MDS Terminated USA | ITA | ESP | AUS 3


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