Therapy Detail

Therapy Name CJM112 + Spartalizumab
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CJM112 CJM112 is a human anti-Interleukin (IL)-17 antibody that inhibits IL-17 downstream signaling (ECTRIMS Oct 8, 2015, Abstract: P655).
Spartalizumab PDR001 Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 50 Spartalizumab (PDR001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT03111992 Phase I LCL161 + Spartalizumab CJM112 + Spartalizumab Spartalizumab Study of Single Agent CJM112, and PDR001 in Combination With LCL161 or CJM112 in Patients With Multiple Myeloma Recruiting
NCT02900664 Phase I Nazartinib + Spartalizumab CJM112 + Spartalizumab Spartalizumab + Trametinib Canakinumab + Spartalizumab A Study of PDR001 in Combination With CJM112, EGF816, Ilaris (Canakinumab) or Mekinist (Trametinib) Recruiting